Document Type : Research Paper

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Department of Pharmacy, Faculty of Medical Science, Kazan Federal University, Russia

Received: 26 March 2017                      Revised: 03 May 2017                        Accepted: 01 June 2017

 10.22034/MBT.2017.60368                                                                      XML Files


In situ gel forming systems have been widely investigated as vehicles for sustained drug delivery. In situ gel formation occurs due to one or combination of different stimuli like pH change, temperature modulation and solvent exchange. So, In situ gelling system via different route such as oral, nasal, ophthalmic etc can be formulated. In the present research work Oral Floating Insitu gel of Tramadol Hydrochloride was formulated using Eudragit L100, Eudragit S100, Eudragit RSPO, Ethyl cellulose, HPMC K100M. The optimized batch gave drug release for 12 hrs in the polymer combination of Sodium Alginate 2% and Ethyl Cellulose 2.5%. In vivo study was performed by providing the formulation to rabbit and then X-ray was taken for the confirmation of formation of gel in stomach and floating of dosage form for 12 hrs. And it was found to be floating for more than 12 hrs. The batch was found to be stable for 6 months in accelerated stability study.