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Rose Scientific Publication, Melbourne, Australia Medbiotech Journal 2209-2528 01 02 2017 06 01 Study of Physicochemical Characters of in-situ Gel of Tramadole Hydrochloride 49 56 109482 10.22034/MBT.2017.60368 EN Vladimir Nesterenko Department of Pharmacy, Faculty of Medical Science, Kazan Federal University, Russia Pavel Lebanov Department of Pharmacy, Faculty of Medical Science, Kazan Federal University, Russia Journal Article 2017 03 26 In situ gel forming systems have been widely investigated as vehicles for sustained drug delivery. In situ gel formation occurs due to one or combination of different stimuli like pH change, temperature modulation and solvent exchange. So, In situ gelling system via different route such as oral, nasal, ophthalmic etc can be formulated. In the present research work Oral Floating Insitu gel of Tramadol Hydrochloride was formulated using Eudragit L100, Eudragit S100, Eudragit RSPO, Ethyl cellulose, HPMC K100M. The optimized batch gave drug release for 12 hrs in the polymer combination of Sodium Alginate 2% and Ethyl Cellulose 2.5%. In vivo study was performed by providing the formulation to rabbit and then X-ray was taken for the confirmation of formation of gel in stomach and floating of dosage form for 12 hrs. And it was found to be floating for more than 12 hrs. The batch was found to be stable for 6 months in accelerated stability study. Tramadol hydrochlotide in situ Gel in vivo study http://www.medbiotech.net/article_109482_2d88cf7639891bb608068cf8e4bd5e63.pdf